Chemotherapy related effects
- Side effects
- Chemotherapy related effects
- Anatomy
- Structure
- Function
Chemotherapy related effects
Chemotherapy related effects
Chemotherapy is sometimes referred to as the treatment that may make you feel sick in order to get better. Most people fear its side effects, partially because people only hear about the most extreme side effects.
Keep in mind that not everyone experiences serious side effects and that any discomfort is usually temporary.
Side effects vary in type and severity from person to person and from medication to medication. Damage to normal, healthy cells is the cause of side effects. To learn more, see our section on side effects or visit chemoready.ca, a specialized website on the subject.
Chemotherapeutic agents
- Docetaxel (Taxotere): Side effects associated with docetaxel use include neutropenia (decrease in white blood cells), fatigue, hair loss, diarrhea, neuropathy (nerve disorder), limb edema (swelling of tissues due to water retention), and nail dystrophy.
- Cabazitaxel (Jevtana): Side effects associated with its use include fatigue, diarrhea, hematuria (blood in the urine), anemia, neutropenia (decrease in white blood cells), hair loss, and limb edema (swelling of tissues due to water retention).
Hormone therapy drugs used in combination
- Abiraterone (Zytiga): Presents more specific adverse effects such as hypertension, water retention and edema (swelling of tissues due to water retention), fatigue, urinary tract infection, cardiac arrhythmia, and liver damage.
- Enzalutamide (Xtandi): Can lead to headaches, hot flashes, hypertension, back pain, respiratory tract infection, anxiety, diarrhea, fatigue, seizures, blood in the urine, and edema.
- Apalutamide (Erleada): Can cause hot flashes, joint pain, diarrhea, nausea, fatigue, loss of appetite, itching, and weight loss.
- Darolutamide (Nubeqa): May cause pain, unusual fatigue, or skin rash and redness.
Some men may experience all the side effects, while others may experience only a few or none at all. Others may experience different side effects.
Increased risk of infection
You will be asked to monitor your temperature regularly and to inform your doctor if you notice wounds that are not healing. The increased risk of infection is due to the decrease in your white blood cells (neutropenia).
What you can do
- Wash your hands often and/or use an antiseptic gel.
- Immediately clean any cuts with soap and water, and apply antiseptic.
- Avoid crowds and people with infections.
- Trim your nails carefully to avoid cuts.
- Use an electric razor to shave.
- Wash and peel raw fruits and vegetables.
- Do not eat undercooked meat.
- Do not clean cat litter boxes or bird cages.
Fatigue
If you feel tired, take care of yourself emotionally and physically. Limit the number of visitors or the duration of visits and rest several times during the day.
What you can do
- Physical activity can help cope with fatigue.
- Try to conserve your energy by delegating as many tasks as possible or making them easier (e.g., sit down while preparing meals, get someone to drive you to your treatments).
Anemia
Chemotherapy causes anemia in some men. When the number of red blood cells or the hemoglobin concentration is low, the body tissues do not get enough oxygen. This results in fatigue and shortness of breath.
What you can do
- Iron supplements are provided in the form of tablets or directly intravenously, depending on tolerance and circumstances.
- The iron level can only be improved through diet when iron deficiency is due to an unreasonable diet. Eat a balanced diet. Follow your doctor’s and nurse’s instructions for appropriate nutrition and, if recommended, for nutritional supplements.
Gastrointestinal problems
Nausea and vomiting may occur within hours after your chemotherapy and usually last for about 24 hours. Medications can prevent these effects in many men.
Diarrhea may occur shortly after the start of your chemotherapy and may last up to two weeks after treatment.
What you can do
- Discuss it with your healthcare team. Medications may be prescribed.
- Ask to meet with a nutritionist if you haven’t already.
- Practice physical or relaxation activities (yoga, meditation) between treatments.
Mouth ulcers
Regular and thorough mouth hygiene can help prevent pain and reduce infection. The healthcare team provides guidance on the frequency of mouth cleaning and rinsing and on the products to use. Analgesics or special oral solutions may be necessary to relieve pain. A special mouthwash can help minimize them.
What you can do
- Avoid acidic, salty, sour, or spicy foods.
- Drink plenty of fluids. This will help heal the ulcers.
- Remove your dentures frequently to rest your gums.
- Keep your mouth moist. If your mouth is dry, suck on an ice pop or hard candy.
Nail changes
Nail changes are common during chemotherapy and can affect fingernails and toenails. Your nails may darken, yellow, become brittle, crack, develop ridges, or partially separate from their beds. Nail darkening usually fades a few months after chemotherapy.
What you can do
- Use a cuticle cream rather than tearing or cutting them.
- Protect your nails by wearing gloves when washing dishes, gardening, or doing other household chores.
- Most men do not have late effects after chemotherapy, but some may experience numbness or tingling in the hands and feet.
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Sources and references
Last medical and editorial review: April 2024. See our web page validation committee and our collaborators by clicking here.
On this page:
Discover our animated video!
Symptoms, risk and screening
Are you over 50 years old, or have you been having urinary problems for some time now? This video is for you! Several diseases can affect your prostate, and it’s important to detect them early. Let’s take a closer look.
Anatomy
What is the prostate
The prostate is a gland:
- Located between the bladder and the penis, just in front of the rectum;
- Formed of 2 lobes which surround the urethra, a canal that runs through the center of the prostate, from the bladder to the penis, letting urine and sperm flow out of the body;
- The size of a walnut, which grows larger in size in your forties;
- That has a soft, spongy texture to the touch like a small, ripe plum.
The prostate is made of:
- Gland cells that secrete liquids for ejaculation;
- Muscle cells that participate in the evacuation of your sperm during ejaculation;
- Fiber cells that maintain the structure of the gland.
Around the prostate, we find:
- The seminal vesicles, glands that produce sperm and that are located on either side of the prostate;
- The vas deferens, the tube that carries sperm from the testicle to the seminal vesicles;
- The nerve bundles that control your bladder and erectile function and that are located on either side of your prostate.
Structure
Three main zones of the prostate
Peripheral zone
- The peripheral zone is the largest area of the prostate. It can easily be felt by the doctor during a digital rectal exam (DRE).
- Most prostate cancers start in the peripheral zone.
Transition zone
- This is the area located in the middle of the prostate, between the peripheral and central areas. It surrounds your urethra that runs through the prostate.
- With age, the transitional area increases in size until it becomes the largest portion of your prostate. This is called benign prostatic hyperplasia (BPH) or enlarged prostate.
Central zone
- It is the part of the prostate that is farthest from the rectum. This is why prostate tumors located in this area can not be felt by the doctor during a digital rectal examination.
- If the doctor is in doubt, the following information will help decide if additional investigation is necessary:
- Your PSA level
- Your age and family history
- Your ethnic origin
Fonction
In short
Your fertility and natural fertilization
- It produces … a prostatic fluid rich in enzymes, proteins and minerals that nourishes and protects your spermatozoa.
- It makes … a protein (APS) that is used to liquefy your sperm to facilitate the mobility of your spermatozoa.
- It allows … ejaculation by contracting.
- It promotes … fertility through its enzymes facilitating the penetration of sperm through the cervix.
- It is not related to the mechanism of erection. Therefore, the origin of erectile dysfunction lies elsewhere.
Additional details
Exocrine Function
The prostate is made up of thousands of tiny fluid-producing glands. Specifically, the prostate is an exocrine gland. Exocrine glands are so-called because they secrete through ducts to the outside of the body (or into a cavity that communicates with the outside). Sweat glands are another example of an exocrine gland.
The fluid that the prostate gland produces forms part of semen, the fluid that carries sperm during orgasm. This fluid, produced in the prostate, is stored with sperm in the seminal vesicles. When the male climaxes, muscular contractions cause the prostate to secrete this fluid into the urethra, where it is expelled from the body through the penis.
Urine Flow
The prostate wraps itself around the urethra as it passes from the bladder to the penis. Prostatic changes can affect urine flow. Increasing the size of the prostate or muscle tone may impede the flow of urine due to the close anatomical relationship between the urethra and the prostate.
Prostate Specific Antigen (PSA)
The prostate also produces a protein called prostate-specific antigen (PSA). PSA is released with the ejaculatory fluid and can also be traced in the bloodstream. The testing of PSA levels in the blood is used to detect prostate cancer. The level of PSA in the blood is usually measured in nanograms of PSA per milliliter of blood (ng/mL).
A raised PSA level
Usually, a PSA rate of less than 4 nanograms per milliliter of blood is normal, but age should also be taken into consideration as PSA levels gradually increase with age. A rise in PSA concentration may indicate the presence of:
- An enlarged prostate (benign prostatic hyperplasia)
- An inflammation or infection of the prostate (prostatitis)
- A prostate cancer
Your doctor will have you undergo other tests to determine the exact cause of the increase in your PSA.
We are here for you
You have questions or concerns? Don’t hesitate. Contact us at 1-855-899-2873 to discuss with one of our nurses specialized in uro-oncology. They are there to listen, support and answer your questions, and those of your family or your loved ones. It’s simple and free, like all of our other services.
Also take the time to visit each of our pages on this website, as well as our YouTube channel, in order to get familiar with the disease, our expert lectures, our section on available resources, the support that is offered to you, our events and ways to get involved to advance the cause..
Staying Informed
Pages that might interest you
Want to know more? Just click on one of the links below.
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The medical content and editorial team at PROCURE
Our team is composed of urologists, and nurses certified in uro-oncology with a deep knowledge of prostate cancer and other diseases related to the genitourinary system. Meet our staff by clicking here.
Sources and references
- Prostate Cancer – Understand the disease and its treatments; Fred Saad, MD, FRCSC and Michael McCormack, MD, FRCSC, 4th et 5th editions
- Canadian Cancer Society
- Prostate Cancer Foundation-PCF.org
- National Cancer Institute-USA
- American Cancer Society
- Memorial Sloan Kettering Cancer Center
- Prostate Cancer UK
Last medical and editorial review: September 2023
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